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LyoNano

From 0.51 to 3.08 m² of shelf area
Condenser capacity up to 60 kg
Output for 2R up to 12,879 vials

GMP production equipment for small batches

Compact construction complying with GMP


CIP / SIP equipment


Wide range of optional equipment


Panels for clean rooms


 

  • GMP Freeze Dryers for Small Batches
  • GMP Freeze Dryers for Small Batches
  • GMP Freeze Dryers for Small Batches
  • GMP Freeze Dryers for Small Batches
  • GMP Freeze Dryers for Small Batches
  • GMP Freeze Dryers for Small Batches

Designed for aseptic batches. Compact and adaptable.

During pharmaceutical and biotechnological development, high value-added and personalized products undergo highly demanding, small-batch processing, with full regulatory compliance obviously required.

Dara-Lyo's LyoNano model is the best choice for customers developing products in these circumstances. The LynoNano is equipped with technology available in our commercial units but for smaller batch sizes, and it is in full compliance with commercial regulation and procedure.

Model LyoNano
Shelf area  0.51 m² 1.03 m² 1.37 m² 1.71 m² 2.05 m² 2.39 m² 2.74 m² 3.08 m²
Shelf dimensions (W x D)  380 x 450 mm 450 x 760 mm
Nº of shelves 3 + 1 6 + 1 4 + 1 5 + 1 6 + 1 7 + 1 8 + 1 9 + 1
Shelves clearance 90 mm 75 mm 105 mm 90 mm 75 mm 105 mm 90 mm 75 mm
Chamber material Stainless steel AISI 316L
Condenser capacity 25 kg 40 kg 60 kg
Condenser temperature -75 ºC
Shelves temperature range from -55 ºC to +85 ºC
Overall dimensions (W x D x H) 1,300 x 1,900 x 1,850 mm 2,000 x 2,500 x 2,500 mm 2,000 x 2,500 x 2,900 mm
Weight 2,000 Kg 3,000 Kg 2,500 Kg

Optional equipment

The chamber

  • Pressureless vessel

  • Cooling by cold water or silicone circuit

Connection with condenser

  • Butterfly valve

  • Mushroom valve

  • Bottom shelf closing

Ice condenser

  • Integrated underneath, on the same floor

  • Integrated on the side, on the same floor

  • Outside, behind the camera, on the same floor

  • Outside, under the camera, on another floor

Shelf movement

  • Closing system hydraulic piston

  • Bellows

  • Connection with automatic charging system

CIP

  • Chamber and condenser cleaning system

  • Recirculation system with heating and/or detergent addition

  • Multiple cleaning cycles

  • CIP independent skid

SIP

  • PED

  • ASME

  • Chamber cool-down after SIP

Plant distribution

  • 1st floor

  • 2 floors

  • Passthrough system

  • Standalone frames

Additional elements

  • ATEX (processes with solvents and/or alcohol)

  • Cold tray loading

  • Frozen tray loading

  • Nucleation technology

Refrigeration

  • Piston compressor

  • Screw compressor

  • Cascade system

  • Liquid nitrogen system

  • Cooling system without PCA

  • Natural gases system

Door

  • Full size door

  • Automatic locking

  • Slot front door (constant loading level)

  • Full size sub-door

  • Cooling by cold water circuit

Process sensors

  • Pirani

  • Capacitive

  • Temperature probes (Pt-100 / Thermocouple)

  • Redundant temperature probes (Pt-100 / Thermocouple)

  • Wireless temperature monitoring

  • Full batch traceability software

  • PAT tools

Control systems

  • Rockwell / Siemens Automation PLC

  • Integrated HMI

  • SCADA

  • Electronic recorder

  • Electronic Server and Think Client

  • Cycle optimization technology

Filter vent system

  • Sterilizable

  • Ports for integrity testing

  • Secondary venting cycle

  • Secondary vent filter

  • Water filter integrity test

Vacuum system

  • Double stage rotary vane pumps

  • Redundancy (additional pump)

  • Dry pumps

  • Roots pumps

Always at your disposal!

We look forward to assisting you with your projects and answering your questions and suggestions. Fill in this form and we will contact you as soon as possible.

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